apalutamide will reduce the extent or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with drugs which can be CYP3A4 substrates may end up in decrease publicity to these medications.Making use of this drug, even as prescribed, can l